Tools to therapeutically harness the human antibody response
Identifieur interne : 000B03 ( Main/Exploration ); précédent : 000B02; suivant : 000B04Tools to therapeutically harness the human antibody response
Auteurs : Patrick C. Wilson [États-Unis] ; Sarah F. Andrews [États-Unis]Source :
- Nature Reviews Immunology [ 1474-1733 ] ; 2012-10.
Abstract
The natural human antibody response is a rich source of highly specific, neutralizing and self-tolerant therapeutic reagents. Recent advances have been made in isolating and characterizing monoclonal antibodies that are generated in response to natural infection or vaccination. Studies of the human antibody response have led to the discovery of crucial epitopes that could serve as new targets in vaccine design and in the creation of potentially powerful immunotherapies. With a focus on influenza virus and HIV, herein we summarize the technological tools used to identify and characterize human monoclonal antibodies and describe how these tools might be used to fight infectious diseases.
Url:
DOI: 10.1038/nri3285
Affiliations:
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Andrews</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Medicine/Rheumatology, University of Chicago, Chicago, Illinois 60637</wicri:regionArea><orgName type="university">Université de Chicago</orgName><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Nature Reviews Immunology</title><idno type="ISSN">1474-1733</idno><idno type="eISSN">1474-1741</idno><imprint><publisher>Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</publisher><date when="2012-10">2012-10</date><biblScope unit="vol">12</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="709">709</biblScope><biblScope unit="page" to="719">719</biblScope><date type="Copyright" when="2012">2012</date></imprint><idno type="ISSN">1474-1733</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1474-1733</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">The natural human antibody response is a rich source of highly specific, neutralizing and self-tolerant therapeutic reagents. Recent advances have been made in isolating and characterizing monoclonal antibodies that are generated in response to natural infection or vaccination. Studies of the human antibody response have led to the discovery of crucial epitopes that could serve as new targets in vaccine design and in the creation of potentially powerful immunotherapies. With a focus on influenza virus and HIV, herein we summarize the technological tools used to identify and characterize human monoclonal antibodies and describe how these tools might be used to fight infectious diseases.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region><settlement><li>Chicago</li></settlement><orgName><li>Université de Chicago</li></orgName></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C." last="Wilson">Patrick C. Wilson</name></region><name sortKey="Andrews, Sarah F" sort="Andrews, Sarah F" uniqKey="Andrews S" first="Sarah F." last="Andrews">Sarah F. Andrews</name><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C." last="Wilson">Patrick C. Wilson</name><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C." last="Wilson">Patrick C. Wilson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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